A new option for scientific blood analysis: fully automatic blood analyzers relieve the pressure of blood analysis in laboratories
Date：2025-03-11
Author：
Blood analysis of laboratory animals plays a crucial role in the vast world of modern medicine and life science research. It not only provides insight into the health of organisms but also serves as an indispensable scientific basis for disease diagnosis and drug development. However, faced with the growing demand for testing and the complex and diverse range of laboratory animal species, traditional blood analysis methods often seem insufficient.
Traditional methods of blood analysis are usually microscopy, which has simple equipment and low cost, but has the disadvantages of being time-consuming, labor-intensive, and susceptible to subjective influences of the experimenter. Modern laboratories usually use fully automatic hematology analyzers for blood cell analysis, which has fast analysis speed, accurate results, and can generate complete reports.
Yuyan Instruments offers fully automated hematology analyzers that can now perform blood analysis in just minutes, a process that once took hours or even days. The instrument's intelligent design makes operation incredibly simple, allowing even non-experts to quickly master it. Furthermore, the data provided by fully automated hematology analyzers is accurate and reliable, unaffected by subjective experimenter influence, providing a solid scientific foundation for research.
02. Mouse and rat performance test report
Performance test report for mice and rats: The precision of important indicators such as WBC, Neu%, Lym%, Bas%, RBC, HGB, etc. is within 3% (unit: CV%); WBC, RBC, HGB, PLT, HCT, etc. have extremely high correlation coefficients (r2>0.999) within the measurable range, and the quantitative accuracy is high.
03Advanced operating software
The device features a user-friendly touchscreen interface, supports LIS data connection, quality control, calibration management, and over 20 user-defined alarm ranges, making it easy to use and get started.
The YAN-505A hematology analyzer offers all the advantages of the YAN-305A, but also adds reticulocyte analysis. Each animal has its own dedicated measurement mode and comes with a clinical performance report, ensuring high-precision analysis of blood cells across all species.
1. The YAN-505A five-category blood analyzer uses advanced multi-angle laser scattering flow cytometry combined with nucleic acid staining. Compared with the electrical impedance method with high error rate, the laser scattering method is not affected by other cells when detecting white blood cells, and the cell information obtained is richer and the results are more accurate. On this basis, combined with nucleic acid staining technology, it can also accurately obtain reticulocyte parameters.Reticulocytes: Reticulocytes are immature red blood cells whose nuclei have been ejected but which still contain genetic material.Reticulocytes are a special type of red blood cells. Reticulocyte detection is of great significance for hematopoietic function and disease detection.
2. The device measures 25 accurate blood routine indices including white blood cell count and red blood cell count through laser scattering flow cytometry (WBC, etc.), electrical impedance method (RBC/PLT), nucleic acid staining laser scattering method (Retic), and colorimetry (HGB);
3.YAN-505A five-category blood test can provide three histograms and five scatter plots.Visually observe the distribution of white blood cells and reticulocytes, as well as the direction of changes in white blood cell count and cell morphology, to improve diagnostic capabilities;
4. The instrument uses advanced multi-angle laser scattering flow cytometry technology. Compared with the electrical impedance method with a high error rate, the laser method for detecting white blood cells is not affected by other cells and is more accurate and safer. On this basis, it is combined with nucleic acid staining technology to accurately obtain reticulocyte parameters;
5. The built-in thermal printer can directly output a blood routine report containing all parameters; it has clinical performance test reports for rats and mice: the precision of important indicators such as WBC, Neu%, Lym%, Bas%, RBC, HGB, etc. is within 3% (unit: CV%); WBC, RBC, HGB, PLT, HCT, etc. have extremely high correlation coefficients within the measurable range (r2>0.999).
02.YAN-305A: Precise Analysis, Five-Classification Scientific Research Tool
Yuyan Instruments' YAN-305A routine blood tester is designed for scientific research laboratories. It can perform fully automatic five-category blood cell analysis on a variety of experimental animals. It supports setting different parameter reference value ranges according to different animal categories, providing convenience for different experiments. The results are more accurate than the three-category analysis and are conducive to diagnosis.
1. The traditional three-part blood routine test cannot completely classify white blood cells, and the white blood cell count is affected by other cells. The five-part blood routine test is more detailed and accurate in white blood cell classification, with more comprehensive indicators and greatly improved cell count accuracy, and can be used as an important criterion for judging specific diseases.
2. The five-differential blood analyzer uses advanced multi-angle semiconductor laser scattering flow cytometry as well as conventional classic electrical impedance method and cyanide-free colorimetry. It can detect and count 23 blood routine indicators such as white blood cells and red blood cell count accurately, with accurate classification and fully automated process.
3. This instrument can output three histograms and four scatter plots (including a separate BAS scatter plot) to visually observe the distribution of white blood cells and changes in the number of white blood cells;
4. The built-in thermal printer can directly output a blood routine report containing all parameters; it has clinical performance test reports for rats and mice: the precision of important indicators such as WBC, Neu%, Lym%, Bas%, RBC, HGB, etc. is within 3% (unit: CV%); WBC, RBC, HGB, PLT, HCT, etc. have extremely high correlation coefficients within the measurable range (r2>0.999).
03.YAN-105A: Three-category basic entry-level model
1. The three-part blood routine test can classify white blood cells into lymphocytes, neutrophils, and intermediate cell groups; it provides three histograms to visually observe the distribution of red blood cells, white blood cells, and platelets, improving scientific research and diagnosis capabilities;
2. The built-in thermal printer can directly output a blood routine report containing all parameters, providing researchers with a full-featured and high-performance solution;
3. Equipped with a 10.4-inch color touch screen, high resolution, Chinese interface; simple operation, user-friendly;
4. Large data storage capacity: The main unit can store up to 50,000 test data sets including graphics. Based on this, it is often suitable for grassroots institutions: with large sample volume fluctuations, limited operator skills, and low maintenance budgets.
04. Comparison of Yuyan blood analyzers
For example, in bacterial and viral infection models, routine blood tests can be used to monitor changes in white blood cells and other blood cells, and assess the severity of infection and immune response. In oncology research, by monitoring changes in white blood cells, platelets and other cells in the blood of experimental animals, the impact of tumors on the body and the effectiveness of treatment can be assessed, providing a scientific basis for optimizing tumor treatment strategies.
02.Drug R&D and Evaluation
During the drug development process, blood analyzers can monitor the effects of drugs on the blood cells of experimental animals. Researchers can evaluate the efficacy, safety and side effects of drugs, providing reliable data support for clinical trials and marketing of drugs.
Hematology analyzers measure changes in the number and morphology of red blood cells, white blood cells, and platelets to assess drug toxicity to the blood system. For example, certain drugs may cause leukopenia or thrombocytopenia, and this information is crucial for drug safety assessment.
03. Research on physiological and pathological mechanisms
In the study of physiological and pathological mechanisms, blood analyzers can reveal the changing patterns of blood cells under physiological conditions and their abnormal manifestations under pathological conditions.
For example, in cardiovascular disease research, by monitoring changes in red blood cell morphology, quantity, and function, we can evaluate heart function and blood circulation status; in immune system disease research, by detecting changes in white blood cell subpopulations, we can understand the body's immune status and immune response process.
Yuyan Instruments' blood analyzers have demonstrated exceptional performance in practical applications. They provide researchers with powerful tools to gain a deeper understanding of the health of organisms and more accurately diagnose diseases. Yuyan Instruments will continue to accompany every researcher on their journey to explore the mysteries of life.
The company's R&D personnel account for 40%, and it has a team of scientists in sensors, chip design, core algorithms, etc., and has professional teams to provide support in product implementation and operation, market and academic promotion, comprehensive product solution design and application. The company has service points covering the whole country and strong technical service capabilities. Its customers include Tsinghua University, Peking University, Zhejiang University, Shanghai Jiaotong University, University of Chinese Academy of Sciences, West China Hospital of Sichuan University, Northern Theater Command General Hospital and other first-class research institutions and hospitals at home and abroad.
Case Study: Challenges in Research Laboratories
In a well-known scientific research laboratory, researchers faced a challenge: with the continuous increase in experimental projects, they needed to perform blood analysis on a large number of experimental animals to obtain accurate data to support their research.However, traditional blood analysis methods are not only time-consuming and labor-intensive, but also difficult to meet the requirements of high precision and high efficiency.Traditional methods of blood analysis are usually microscopy, which has simple equipment and low cost, but has the disadvantages of being time-consuming, labor-intensive, and susceptible to subjective influences of the experimenter. Modern laboratories usually use fully automatic hematology analyzers for blood cell analysis, which has fast analysis speed, accurate results, and can generate complete reports.
Yuyan Instruments offers fully automated hematology analyzers that can now perform blood analysis in just minutes, a process that once took hours or even days. The instrument's intelligent design makes operation incredibly simple, allowing even non-experts to quickly master it. Furthermore, the data provided by fully automated hematology analyzers is accurate and reliable, unaffected by subjective experimenter influence, providing a solid scientific foundation for research.
From scientific research difficulties to breakthroughs: Unveiling the outstanding performance of three blood analyzers from Yuyan Instruments
In the field of hematology analyzers, human clinical devices hold the vast majority of the market share. However, differences in morphology and size between animal and human blood cells can lead to errors in analytical procedures such as cell classification and counting. Therefore, directly analyzing animal blood using a human hematology analyzer can produce misleading results.
Yuyan Instruments has launched a fully automatic blood analyzer tailored for 17 types of experimental animals, including mice, rats, gerbils, hamsters, guinea pigs, ferrets, chinchillas, hedgehogs, rabbits, dogs, cats, monkeys, pigs, cattle, horses, sheep, and camels. It is designed specifically for scientific research laboratories.
The five-category hematology analyzer provides three histograms and five scatter plots. It allows users to visually observe the distribution, quantity, and morphological changes of white blood cells and other blood cells, improving research and diagnosis capabilities.
02. Mouse and rat performance test report
Performance test report for mice and rats: The precision of important indicators such as WBC, Neu%, Lym%, Bas%, RBC, HGB, etc. is within 3% (unit: CV%); WBC, RBC, HGB, PLT, HCT, etc. have extremely high correlation coefficients (r2>0.999) within the measurable range, and the quantitative accuracy is high.
03Advanced operating software
The device features a user-friendly touchscreen interface, supports LIS data connection, quality control, calibration management, and over 20 user-defined alarm ranges, making it easy to use and get started.
Multiple models to choose from
01.YAN-505A: Flagship recommendation, reticulocyte detectionThe YAN-505A hematology analyzer offers all the advantages of the YAN-305A, but also adds reticulocyte analysis. Each animal has its own dedicated measurement mode and comes with a clinical performance report, ensuring high-precision analysis of blood cells across all species.
1. The YAN-505A five-category blood analyzer uses advanced multi-angle laser scattering flow cytometry combined with nucleic acid staining. Compared with the electrical impedance method with high error rate, the laser scattering method is not affected by other cells when detecting white blood cells, and the cell information obtained is richer and the results are more accurate. On this basis, combined with nucleic acid staining technology, it can also accurately obtain reticulocyte parameters.Reticulocytes: Reticulocytes are immature red blood cells whose nuclei have been ejected but which still contain genetic material.Reticulocytes are a special type of red blood cells. Reticulocyte detection is of great significance for hematopoietic function and disease detection.
2. The device measures 25 accurate blood routine indices including white blood cell count and red blood cell count through laser scattering flow cytometry (WBC, etc.), electrical impedance method (RBC/PLT), nucleic acid staining laser scattering method (Retic), and colorimetry (HGB);
3.YAN-505A five-category blood test can provide three histograms and five scatter plots.Visually observe the distribution of white blood cells and reticulocytes, as well as the direction of changes in white blood cell count and cell morphology, to improve diagnostic capabilities;
4. The instrument uses advanced multi-angle laser scattering flow cytometry technology. Compared with the electrical impedance method with a high error rate, the laser method for detecting white blood cells is not affected by other cells and is more accurate and safer. On this basis, it is combined with nucleic acid staining technology to accurately obtain reticulocyte parameters;
5. The built-in thermal printer can directly output a blood routine report containing all parameters; it has clinical performance test reports for rats and mice: the precision of important indicators such as WBC, Neu%, Lym%, Bas%, RBC, HGB, etc. is within 3% (unit: CV%); WBC, RBC, HGB, PLT, HCT, etc. have extremely high correlation coefficients within the measurable range (r2>0.999).
02.YAN-305A: Precise Analysis, Five-Classification Scientific Research Tool
Yuyan Instruments' YAN-305A routine blood tester is designed for scientific research laboratories. It can perform fully automatic five-category blood cell analysis on a variety of experimental animals. It supports setting different parameter reference value ranges according to different animal categories, providing convenience for different experiments. The results are more accurate than the three-category analysis and are conducive to diagnosis.
1. The traditional three-part blood routine test cannot completely classify white blood cells, and the white blood cell count is affected by other cells. The five-part blood routine test is more detailed and accurate in white blood cell classification, with more comprehensive indicators and greatly improved cell count accuracy, and can be used as an important criterion for judging specific diseases.
2. The five-differential blood analyzer uses advanced multi-angle semiconductor laser scattering flow cytometry as well as conventional classic electrical impedance method and cyanide-free colorimetry. It can detect and count 23 blood routine indicators such as white blood cells and red blood cell count accurately, with accurate classification and fully automated process.
3. This instrument can output three histograms and four scatter plots (including a separate BAS scatter plot) to visually observe the distribution of white blood cells and changes in the number of white blood cells;
4. The built-in thermal printer can directly output a blood routine report containing all parameters; it has clinical performance test reports for rats and mice: the precision of important indicators such as WBC, Neu%, Lym%, Bas%, RBC, HGB, etc. is within 3% (unit: CV%); WBC, RBC, HGB, PLT, HCT, etc. have extremely high correlation coefficients within the measurable range (r2>0.999).
03.YAN-105A: Three-category basic entry-level model
The YAN-105A Hematology Analyzer, a fully automated, three-way differential animal blood cell analyzer, is an entry-level product designed specifically for research laboratories. It utilizes classic electrical impedance and cyanide-free colorimetry to detect and count individual white blood cells (WBCs) and accurately obtain 19 blood cell parameters. It offers precise classification and a fully automated process.
1. The three-part blood routine test can classify white blood cells into lymphocytes, neutrophils, and intermediate cell groups; it provides three histograms to visually observe the distribution of red blood cells, white blood cells, and platelets, improving scientific research and diagnosis capabilities;
2. The built-in thermal printer can directly output a blood routine report containing all parameters, providing researchers with a full-featured and high-performance solution;
3. Equipped with a 10.4-inch color touch screen, high resolution, Chinese interface; simple operation, user-friendly;
4. Large data storage capacity: The main unit can store up to 50,000 test data sets including graphics. Based on this, it is often suitable for grassroots institutions: with large sample volume fluctuations, limited operator skills, and low maintenance budgets.
04. Comparison of Yuyan blood analyzers
Multiple models to choose from
In the field of scientific research, the wide range of application scenarios and in-depth analytical capabilities of blood analyzers provide researchers with unprecedented research perspectives and data support.
01.Disease model research
In disease model research, blood analyzers can accurately analyze changes in blood cells in experimental animals (such as mice, rats, and guinea pigs), helping researchers gain a deeper understanding of the occurrence, development, and outcome of diseases.For example, in bacterial and viral infection models, routine blood tests can be used to monitor changes in white blood cells and other blood cells, and assess the severity of infection and immune response. In oncology research, by monitoring changes in white blood cells, platelets and other cells in the blood of experimental animals, the impact of tumors on the body and the effectiveness of treatment can be assessed, providing a scientific basis for optimizing tumor treatment strategies.
02.Drug R&D and Evaluation
During the drug development process, blood analyzers can monitor the effects of drugs on the blood cells of experimental animals. Researchers can evaluate the efficacy, safety and side effects of drugs, providing reliable data support for clinical trials and marketing of drugs.
Hematology analyzers measure changes in the number and morphology of red blood cells, white blood cells, and platelets to assess drug toxicity to the blood system. For example, certain drugs may cause leukopenia or thrombocytopenia, and this information is crucial for drug safety assessment.
03. Research on physiological and pathological mechanisms
In the study of physiological and pathological mechanisms, blood analyzers can reveal the changing patterns of blood cells under physiological conditions and their abnormal manifestations under pathological conditions.
For example, in cardiovascular disease research, by monitoring changes in red blood cell morphology, quantity, and function, we can evaluate heart function and blood circulation status; in immune system disease research, by detecting changes in white blood cell subpopulations, we can understand the body's immune status and immune response process.
Yuyan Instruments, the ideal choice for scientific research laboratories
Whether it is basic research or high-precision analysis, Yuyan Instrument's YAN-105A, YAN-305A and YAN-505A five-category blood analyzers can meet the needs of scientific research laboratories.Yuyan blood analyzer is an ideal choice for scientific research laboratories with its accurate white blood cell classification results, advanced operating system, low sample consumption and powerful data storage capacity.Yuyan Instruments' blood analyzers have demonstrated exceptional performance in practical applications. They provide researchers with powerful tools to gain a deeper understanding of the health of organisms and more accurately diagnose diseases. Yuyan Instruments will continue to accompany every researcher on their journey to explore the mysteries of life.
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Self-developed core creates extraordinary strength
The company's R&D personnel account for 40%, and it has a team of scientists in sensors, chip design, core algorithms, etc., and has professional teams to provide support in product implementation and operation, market and academic promotion, comprehensive product solution design and application. The company has service points covering the whole country and strong technical service capabilities. Its customers include Tsinghua University, Peking University, Zhejiang University, Shanghai Jiaotong University, University of Chinese Academy of Sciences, West China Hospital of Sichuan University, Northern Theater Command General Hospital and other first-class research institutions and hospitals at home and abroad.