Say goodbye to experimental drug waste! Say goodbye to experimental drug waste! Say goodbye to experimental drug waste! Say goodbye to experimental drug waste Neurophysiology research, as a key field in exploring the mysteries of life, is dedicated to revealing the complex functions and mechanisms of the nervous system of organisms.However, the road to neurophysiology research is not smooth. Researchers often face multiple challenges such as inaccurate signal acquisition, complex data analysis, and limited experimental conditions.Especially when studying small animals in a conscious and free-moving state, how to efficiently and accurately collect and analyze their physiological signals has become a key factor restricting research progress.

In this context, Yuyan Instruments provides strong support for neurophysiology research with its comprehensive and excellent one-stop solutions.Yuyan provides small animal EEG/EMG acquisition and analysis systems, providing a one-stop solution for neuroscience researchers to collect physiological signals from awake and freely moving small animals. Yuyan is also committed to developing new tools to simplify measurements, reduce costs and enable new research.

In neuroscience research, collecting electrocortical (EEG) and electromyographic (EMG) data from small animals is a crucial technique for exploring neural mechanisms. By implanting headgear electrodes, we can simultaneously record cortical electrical activity and muscle contraction signals, enabling detailed and comprehensive assessments of sleep, epilepsy, cognitive behavior, and other aspects of animal behavior in various psychiatric disease models.

Yuyan Instruments provides comprehensive neurophysiology solutions

Yuyan Instruments provides a one-stop solution for researchers in neurophysiology research to collect physiological signals from small animals in a conscious and freely moving state. It can provide subsystems including EEG/EMG acquisition and analysis, optogenetics, intracranial chemical substance detection, sleep deprivation, synchronous video acquisition and analysis, FSCV electrochemical neurotransmitter detection, etc.

The product has been cited in thousands of peer-reviewed publications. Its subsystems, including EEG and myoelectric acquisition and analysis, optogenetics, intracranial chemical detection, sleep deprivation, and synchronized video acquisition and analysis, can be used independently or combined in part or in whole into a one-stop solution, offering great flexibility. The following combination is used by numerous laboratories.

EEG/EMG acquisition and analysis solution

The EEG/EMG acquisition and analysis solution for mice and rats is used to record EEG/EMG signals of freely moving mice and rats during sleep, epilepsy, and normal behavior patterns. This solution uses special screw electrodes and head caps to collect EEG from the animal's cortex/deep nuclei and EMG from the back of the neck muscles. Yuyan Instruments can provide both wireless and wired EEG/EMG acquisition and analysis solutions.

01.Solution Advantages
1. Widely used and widely used: The EEG/EMG acquisition and analysis solution is used by many domestic laboratories. It is a common basic solution that can be configured with professional sleep software for sleep research and epilepsy software for epilepsy research, which is highly flexible.
2. Excellent hardware performance: Compared with similar equipment, the EEG/EMG acquisition system has unique advantages in the signal quality and presentation continuity of EEG/EMG.

02. Sleep analysis software
Sirenia® Sleep Pro sleep analysis software uses the gold standard sleep analysis method. Based on the strength of EEG delta waves, theta waves, and electromyographic signals, and based on multiple scoring tools, it quickly and accurately scores and analyzes the various sleep phases of animals, obtaining sleep-related data such as animal sleep-wake phase diagrams, sleep duration, number of awakenings, etc.

The software provides a variety of effectiveness sleep scoring tools. Cluster scoring and threshold scoring can quickly screen large amounts of experimental data. Spectral graphs, heat maps, and sleep phase graphs can assist experimenters in manually and accurately analyzing the screened data.

03. Epilepsy-specific analysis software

Professional epilepsy analysis software provides three epilepsy analysis methods: Power, Line Length, and Amplitude. Assisted by tools such as spectrum graphs and heat maps, it can perform automated power analysis and line length analysis on EEG/EMG signals, greatly reducing the time required to identify and analyze epileptic events.

The software enables customized high-quality graphs for use in papers, presentations, and everyday research, and is compatible with EDF files generated by third-party devices recording EEG/EMG.

EEG/EMG acquisition and analysis + sleep deprivation protocol

The system combines sleep deprivation with EEG and EMG acquisition and analysis to form a one-stop electrophysiological system, which can synchronously record the EEG and EMG signals of sleep, epilepsy and normal behavior patterns of freely moving mice before, during and after the sleep deprivation process, and perform professional sleep/epilepsy analysis.

01.Solution Advantages
EEG/EMG acquisition and analysis + sleep deprivation solution is compatible with sleep deprivation hardware and software modules based on the EEG/EMG acquisition and analysis system.This program can be used to model sleep deprivation, and sleep deprivation can be controlled manually or by schedule.


The unique advantage of this solution is that it is compatible with the feedback-type sleep deprivation software module, and the power thresholds of EEG and EMG can be set to trigger the rotation of the sleep deprivation rod, so as to achieve the effect of interfering with sleep but not interfering with waking activities.

EEG/EMG acquisition and analysis + sleep deprivation + synchronized video solution

Combine sleep deprivation, synchronized video, EEG and EMG acquisition and analysis to form a one-stop electrophysiological system.The solution can meet the research needs of multiple departments and includes two application directions:
1. Select the combination of sleep deprivation and EEG and EMG data collection for sleep model research;
2. Select the combination of synchronous video + EEG and EMG acquisition for epilepsy model research.

01.Solution Advantages
This solution can meet the neuroscience electrophysiology acquisition needs of multiple departments within a single institution. It combines sleep deprivation, synchronized video, and EEG and EMG data acquisition, along with specialized sleep and epilepsy analysis software for analysis, enabling more flexible experimental design.

For professional analysis of epilepsy, when the generated synchronized video and original EEG and EMG files are played back and analyzed, the video playback and EEG and EMG signals are synchronized in time without any delay, making the researchers' epileptic seizure analysis results more scientific and accurate.

02.XY Video Tracking Software
XY video tracking software can accurately detect and analyze the movement trajectory of animals in cages. It can track the movement trajectory of animals in real time and perform subsequent trajectory analysis on previously captured videos. Test and analysis parameters include thermal spectra of animal activities, activity trajectories, activity distance and speed, quadrant analysis, and custom area analysis.

EEG/EMG acquisition and analysis + intracranial chemical detection + synchronous video solution

Bio-enzyme sensors can be used to monitor changes in neurochemical concentrations in the brains of awake mice and rats. With their rapid response, high specificity, and real-time accuracy, they are a powerful tool for in vivo detection of changes in neurochemical concentrations. Yuyan Instruments provides a one-stop system that combines EEG and EMG acquisition and analysis, intracranial chemical detection, and synchronized video, enabling users to quickly record, acquire, and analyze experimental data.

The picture above shows the captured video and EEG, EMG and intracranial chemical detection data displayed in real time on the software.

01.Solution Advantages

The solution has good scalability and can simultaneously detect intracranial chemicals while performing EEG/EMG and video acquisition. The detectable chemicals include: glutamate, glucose, lactate, ethanol, etc. The detection concentration requirement is low and it has three major advantages:

1. Linear Response: Each biosensor has a good linear response relationship within the physiologically relevant concentration range of the active substance;

2. High Specificity: Various endogenous electroactive interfering substances can be effectively shielded, with high specificity;

3. Fast Response: The response time to changes in chemical substance concentration is within seconds, truly achieving real-time detection.

Lactate and Glucose Biosensors: Biosensors are used to record changes in lactate and glucose concentrations from the brain of individual animals in synchronization with EEG/EMG.

02. Types of biosensors

EEG/EMGEEG/EMG acquisition and analysis + intracranial chemical detection + optogenetics program

The EEG/EMG acquisition, intracranial chemical monitoring, and optogenetics protocol is available for both mice and rats. Researchers can seamlessly combine optogenetic stimulation experiments with bioelectrical recordings and intracranial chemical monitoring to adapt to different experimental models.

01.Solution Advantages

1. Using LED fiber optic probe, there are 7 different wavelengths of light source to choose from;
2. Multi-color expansion, adding fiber probes, no need to replace the host, lower cost than traditional laser optogenetics;
3. The LED light source is close to the tip, and the attenuation of optogenetics is lower than that of traditional lasers;
4. The one-stop system integrated with EEG/EMG and chemical substance detection solves the problem of real-time synchronous display of optogenetic stimulation markers. It has high integration and the system only needs a single set of transmission cables. There is no problem of cable entanglement and knotting when using multiple separate systems synchronously.

Yuyan Instruments provides a complete solution for neurophysiological research

The high flexibility and scalability of the EEG and EMG acquisition system can easily adapt to the unique needs of different laboratories.Whether it is the basic acquisition and analysis of physiological signals in basic research or complex multi-technology joint research, Yuyan Instruments can provide tailored comprehensive solutions.You can flexibly choose different subsystem combinations based on your research direction and experimental needs, such as combining intracranial chemical detection to study the association between neurochemical substances and physiological signals, or using optogenetics to explore the relationship between neural circuits and behavior.
Yuyan Instruments specializes in animal research instruments, providing comprehensive and superior one-stop solutions and strong support for neurophysiological research. From precise EEG/EMG acquisition and analysis to advanced optogenetics and intracranial chemical detection technologies, Yuyan Instruments offers a full suite of equipment and technical support, paving a smoother and more efficient research path for researchers and driving new breakthroughs in neurophysiological research.

Self-developed core creates extraordinary strength

Shanghai Yuyan Scientific Instrument Co., Ltd., as a leading manufacturer of scientific research equipment in the industry, has been adhering to the core concept of "innovation drives development, and self-research creates quality" for 14 years since its establishment in 2010. It is committed to the independent research and development and production of scientific instruments. Its current product line covers multiple scientific research and application fields such as experimental animal husbandry, physiological signal acquisition, and neuroscience research. Not only does it continuously optimize and upgrade conventional instruments, but it also dares to explore cutting-edge technologies and has launched a series of high-end scientific instruments with independent intellectual property rights. The company's R&D personnel account for 40%, and it has a team of scientists in sensors, chip design, core algorithms, etc., and has professional teams to provide support in product implementation and operation, market and academic promotion, comprehensive product solution design and application. The company has service points covering the whole country and strong technical service capabilities. Its customers include Tsinghua University, Peking University, Zhejiang University, Shanghai Jiaotong University, University of Chinese Academy of Sciences, West China Hospital of Sichuan University, Northern Theater Command General Hospital and other first-class research institutions and hospitals at home and abroad.