At a cancer research center, researchers use ultrahigh-frequency ultrasound imaging to precisely locate tumor boundaries, then perform targeted ablation using accompanying ultrasound therapy equipment and observe the ablation effects through ultrasound imaging. This closed-loop "imaging-therapy-imaging" system is becoming a new paradigm in life science research. This article will focus on the ultrahigh-frequency small animal ultrasound imaging system and explain how it is building a new ultrasound research ecosystem, driving breakthroughs in cardiovascular, oncology, and embryology research.

Ultra-high frequency imaging: Three core advantages of scientific imaging

01Super-resolution ultrasound imaging: an innovation that breaks through physical limits
Traditional ultrasound, limited by its wavelength, struggles to capture blood vessels smaller than 100 microns in diameter. The Yuyan Sonorover super-resolution imaging system leverages powerful image processing capabilities to deliver exceptional ultra-high-resolution ultrasound imaging, clearly capturing tiny tissue structures and fine anatomical details, enabling precise imaging.

02 fUS functional brain imaging: Decoding the brain's "language" in real time
Unlike fMRI's minute-long latency, the Yuyan Sonorover super-resolution imaging system's fUS technology captures dynamic changes in cerebral blood flow at 100 frames per second. fUS functional ultrasound imaging uses ultrafast ultrasound and ultrasensitive blood flow imaging to capture minute changes in brain tissue blood flow. Based on neurovascular coupling mechanisms, it can capture the state of brain function in real time.

03 Photoacoustic Imaging: The Perfect Fusion of Optics and Acoustics
High-frequency photoacoustic ultrasound dual-modality imaging is an innovative imaging method that combines high-frequency ultrasound and photoacoustic technology.Yuyan's Sonorover super-resolution imaging system clearly displays tissue structure through fine spatial resolution, while photoacoustic technology captures molecular functional information such as blood oxygen levels based on the photoacoustic effect. The two complement each other and can achieve high-resolution, multi-dimensional imaging of tissues.
       

Imaging toolbox covering all scientific research scenarios

01 Conventional Ultrasound Imaging Module
1. Ultrasound imaging: visualization of basic anatomical structures
2. M-ultrasound imaging: uses time as the horizontal axis to display the movement trajectory of structures such as the heart
3. Color/Power Doppler: Blood flow direction and velocity mapping (vascular patency assessment)
4. Pulse/Tissue Doppler: Accurately measure blood flow velocity and tissue motion

02 Advanced Function Module
1. Myocardial strain imaging: quantitative analysis of myocardial deformation and detection of early cardiac dysfunction;
2.3D cerebral blood flow imaging: three-dimensional display of the distribution and dynamic changes of blood flow in the whole brain;
3. High-frequency angiography: Improves angiography frame rate and captures microvascular perfusion details;
4. Elastography: Assessing changes in tissue stiffness (e.g., tumor identification)

Innovative technology: Redefining the boundaries of ultrasound imaging

01Hardware Breakthrough
1. 256-channel array element design: Compared with traditional systems, it can capture more subtle information and achieve higher image resolution;
2. High-frequency probe technology: using piezoelectric ceramics, the sensitivity is greatly improved;

3. Multi-channel architecture: effectively enhances data processing capabilities, making imaging faster and more stable

02Algorithm Innovation
1. Super-resolution reconstruction algorithm: One-click optimization of contrast and resolution, improving image clarity and detail, and enhancing the accuracy of diagnosis and scientific research;
2. Brain function fUS technology: It can integrate brain function ultrasound imaging technology and systems to support rapid brain function ultrasound imaging;

3. Photoacoustic fusion algorithm: combines optical and ultrasound technologies to provide high-resolution images of tissue structure and function

03Design Concept
1. Integrated operating table: optional integrated universal bracket and temperature-controlled mouse plate (supports ECG monitoring);
2. Imaging-treatment linkage: seamlessly connects to the UPG100 therapeutic device to achieve a closed loop of "positioning-intervention-verification";
3. Full Chinese system: localized operation interface and customer service support to lower the threshold for use

Real scientific research scenario case display

01Myocardial strain imaging
Ultrasound is used to track the movement of the myocardium during cardiac contraction and relaxation, and the strain values in different directions (longitudinal, longitudinal, and circumferential) are calculated.

02Super-resolution ultrasound imaging
Super-resolution imaging of rat cerebral blood flow allows for precise observation of cerebral blood flow dynamics and real-time physiological status monitoring.

03Super-resolution imaging of cerebral ischemia in rats

Super-resolution imaging of rat cerebral blood flow allows for precise observation of cerebral blood flow dynamics and real-time physiological status monitoring.

04 fUS functional brain ultrasound imaging

The experiment of periodic stimulation of rat whiskers was used to obtain the corresponding relationship between the change of blood volume in the rat brain region (S1BF) and tactile stimulation.

05 fUS for epilepsy tracking
fUS functional brain imaging was used to track the course of epileptic seizures in awake rats.

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UPG100 Ultrasonic Therapeutic Device——Programmable "Acoustic Scalpel"
The UPG100 series animal ultrasound therapeutic device can generate high-power pulsed ultrasound with adjustable parameters such as frequency, amplitude, pulse length, and repetition rate. It can be applied to animal scientific research such as non-invasive ultrasound regulation and treatment. It has been widely used in cutting-edge scientific experimental research such as non-invasive neural regulation, targeted drug delivery, blood-brain barrier opening, sonodynamic therapy, rehabilitation therapy, ultrasonic thrombolysis, and ultrasonic ablation.

01Three major technical killers

1. Multi-channel programmable: supports 1-2048 channels;

2. Transducer array: head-mounted (neuromodulation in awake animals), catheter-based (intravascular thrombolysis), focused (tumor ablation), planar (petri dish/irradiation experiments);

3. Synchronization/trigger function: Provide trigger/synchronization interface to realize device linkage with other monitoring devices

Company strength: technical support from the Chinese Academy of Sciences

Yuyan Instruments has cooperated deeply with the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences on the ultrasound system project, helping the ultrasound system to achieve commercialization from research and development to implementation. It has played an indispensable role in market promotion, sales and product technical support, and provides one-stop services before, during and after sales of products. It is the China regional manager of Shenzhen Huanying Medical Technology Co., Ltd. for small animal ultrasound imaging system-related equipment in the scientific research field.

Since its founding, Shenzhen Huanying Medical has been committed to the research, development, and industrialization of cutting-edge, high-end biomedical ultrasound technologies. With over two decades of accumulated experience, the company has developed a deep technical foundation in innovative applications such as ultrasound catheter imaging and high-resolution imaging. Focusing on research ultrasound, interventional ultrasound, and ultrasound laboratory automation, the company has developed a comprehensive ultrasound product line. As a national high-tech enterprise incubated by the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, the company has established a comprehensive platform for the development and industrialization of ultrasound transducers and ultrasound imaging/therapy systems.

Huanying Medical's core technologies have been approved for numerous major ultrasound-related projects at the national, provincial, ministerial, and municipal levels. The company boasts extensive technical expertise in innovative applications such as ultrasound catheter imaging, high-resolution imaging, ultrasonic pipetting, and ultrasound therapy. As an innovation engine and technological benchmark in the ultrasound field, Huanying Medical, with its core focus on "full-chain solutions," continuously defines the future of ultrasound technology, from underlying probe algorithms to clinical implementation, from hardware innovation to ecosystem development.

Self-developed core creates extraordinary strength

Shanghai Yuyan Scientific Instrument Co., Ltd., as a leading manufacturer of scientific research equipment in the industry, has been adhering to the core concept of "innovation drives development, and self-research creates quality" for 14 years since its establishment in 2010. It is committed to the independent research and development and production of scientific instruments. Its current product line covers multiple scientific research and application fields such as experimental animal husbandry, physiological signal acquisition, and neuroscience research. Not only does it continuously optimize and upgrade conventional instruments, but it also dares to explore cutting-edge technologies and has launched a series of high-end scientific instruments with independent intellectual property rights. The company's R&D personnel account for 40%, and it has a team of scientists in sensors, chip design, core algorithms, etc., and has professional teams to provide support in product implementation and operation, market and academic promotion, comprehensive product solution design and application. The company has service points covering the whole country and strong technical service capabilities. Its customers include Tsinghua University, Peking University, Zhejiang University, Shanghai Jiaotong University, University of Chinese Academy of Sciences, West China Hospital of Sichuan University, Northern Theater Command General Hospital and other first-class research institutions and hospitals at home and abroad.