Acute lung injury (ALI) is a severe lung inflammation caused by bacteria and respiratory tract infection, which can lead to significant damage to the alveolar epithelium and endothelial barrier, with a mortality rate of up to 40%.ALI is usually caused by a variety of causes, including infection, trauma, inhalation injury, and some medical procedures.These diseases are characterized by lung inflammation, damage to the alveolar epithelial and endothelial barriers, and subsequent pulmonary edema and hypoxemia.

Yuyan Instruments' Microsprayer Aerosolizer, also known as an intratracheal aerosol drug delivery device, is a device specifically designed for small animals such as mice, rats, and guinea pigs that can accurately deliver intratracheal aerosol drug delivery.The quantitative liquid can be atomized through the aerosol atomization micro nozzle integrated in the stainless steel capillary cannula. The capillary cannula can penetrate deep into the animal to the bronchial bifurcation to achieve quantitative atomization into aerosol drug delivery in the trachea.Compared with traditional oral or injection administration, drugs can act directly on the lungs and are suitable for lung physiology, pathology, and pharmacology research. According to the different states of administration, they can also be divided into liquid administration and dry powder administration.

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a high mortality rate.FDA-approved drugs nintedanib and pirfenidone (PFD) can delay disease progression by inhibiting the overactivation of fibroblasts. However, due to the low drug accumulation level in the target site and the short duration of action of conventional administration methods, they cannot significantly improve patient survival.Therefore, it is crucial to find new treatment pathways, and the emergence of nanomedicine has changed this.

At the forefront of medical research, the treatment of acute lung injury (ALI) has always been a difficult problem.null null As the core pathological link in the development of ALI, the intense inflammatory response is closely related to oxidative stress, making the generation of excessive reactive oxygen species (ROS) a key target for treatment.