When an animal or human encounters a sudden and intense external stimulus, such as a deafening roar or a blinding flash of light, the body reacts immediately and without hesitation. An animal might instantly tense its muscles and jump in surprise; a human might involuntarily tremble, blink, or even experience a sudden acceleration of their heartbeat. This is the basic startle reflex. This primitive reaction actually hides the brain's unique "filtering" ability—sensory-motor gating.

As the core organ of the organism's neural control, the brain plays a vital role in behavioral activities, sensory feedback, and psychological activities.The study of brain function and structure has always been the focus of researchers. Traditional research tools include magnetic resonance imaging (MRI) and electroencephalogram (EEG).

At a cancer research center, researchers use ultrahigh-frequency ultrasound imaging to precisely locate tumor boundaries, then perform targeted ablation using accompanying ultrasound therapy equipment and observe the ablation effects through ultrasound imaging. This closed-loop "imaging-therapy-imaging" system is becoming a new paradigm in life science research. This article will focus on the ultrahigh-frequency small animal ultrasound imaging system and explain how it is building a new ultrasound research ecosystem, driving breakthroughs in cardiovascular, oncology, and embryology research.

Neurophysiology research, as a key field in exploring the mysteries of life, is dedicated to revealing the complex functions and mechanisms of the nervous system of organisms.However, the road to neurophysiology research is not smooth. Researchers often face multiple challenges such as inaccurate signal acquisition, complex data analysis, and limited experimental conditions.Especially when studying small animals in a conscious and free-moving state, how to efficiently and accurately collect and analyze their physiological signals has become a key factor restricting research progress.

Pain is an unpleasant response of the body to damaged tissue or potential damage. It is a complex physiological and psychological activity and one of the most common clinical symptoms.More than 20% of the world's population suffers from pain, which places a huge burden on health and the economy.[1].However, current pain assessment and treatment methods still cannot meet clinical needs, and there is still a need to further explore the neural mechanisms of pain and develop analgesic drugs.

In the process of exploring the brain, the most complex and mysterious organ in the human body, the brain stereotaxic device, as a key device in the field of neuroscience research, plays an irreplaceable role. Like a precise "navigator," it allows researchers to break through the complexity of brain structure and deeply explore its mysteries.