At a cancer research center, researchers use ultrahigh-frequency ultrasound imaging to precisely locate tumor boundaries, then perform targeted ablation using accompanying ultrasound therapy equipment and observe the ablation effects through ultrasound imaging. This closed-loop "imaging-therapy-imaging" system is becoming a new paradigm in life science research. This article will focus on the ultrahigh-frequency small animal ultrasound imaging system and explain how it is building a new ultrasound research ecosystem, driving breakthroughs in cardiovascular, oncology, and embryology research.

In neuroscience, assessing animal behavior is key to unlocking neural mechanisms and drug effects.The Open Field Test (OFT) is a classic experimental method. Since it was proposed by Calvin S. Hall in 1932, it has become a powerful tool for studying the anxiety level, motor ability and drug intervention effects of rodents.This experimental paradigm builds a bridge between behavior and neural mechanisms by quantifying the spontaneous behavior patterns of animals in a novel environment.null

Recently, a research team from the School of Traditional Chinese Medicine of Capital Medical University published an article titled "Investigation of the material basis and mechanism of Qingfei Paidu granules in treating LPS-induced acute pneumonia using UPLC-Q-TOF-MS/MS, network pharmacology, molecular docking and experimental verification" in the renowned journal Journal of Pharmaceutical and Biomedical Analysis. The article describes the research on the mechanistic principles of Qingfei Paidu Granules (QFPDG), a traditional Chinese medicine for treating lung diseases, including drug purification, component analysis, and in vitro and in vivo experiments. Let's explore the advancements in this traditional formula.

The Morris water maze was first designed by British psychologist Morris in the 1980s and used to assess learning and memory. It forces experimental animals to swim in a water tank, search for, and memorize the location of a hidden platform...

Neurophysiology research, as a key field in exploring the mysteries of life, is dedicated to revealing the complex functions and mechanisms of the nervous system of organisms.However, the road to neurophysiology research is not smooth. Researchers often face multiple challenges such as inaccurate signal acquisition, complex data analysis, and limited experimental conditions.Especially when studying small animals in a conscious and free-moving state, how to efficiently and accurately collect and analyze their physiological signals has become a key factor restricting research progress.

Pain is an unpleasant response of the body to damaged tissue or potential damage. It is a complex physiological and psychological activity and one of the most common clinical symptoms.More than 20% of the world's population suffers from pain, which places a huge burden on health and the economy.[1].However, current pain assessment and treatment methods still cannot meet clinical needs, and there is still a need to further explore the neural mechanisms of pain and develop analgesic drugs.