Acute lung injury (ALI) is a severe lung inflammation caused by bacteria and respiratory tract infection, which can lead to significant damage to the alveolar epithelium and endothelial barrier, with a mortality rate of up to 40%.ALI is usually caused by a variety of causes, including infection, trauma, inhalation injury, and some medical procedures.These diseases are characterized by lung inflammation, damage to the alveolar epithelial and endothelial barriers, and subsequent pulmonary edema and hypoxemia.

In recent years, the intermittent oxygen concentration control system independently developed by Shanghai Yuyan Instrument has been used in many domestic laboratories and has been widely praised.By precisely controlling the output of gas concentration, it can maintain any oxygen concentration or switch between multiple oxygen concentrations. It can be used for various experiments related to oxygen concentration in experimental animals such as mice and rats.Gas flow, concentration, time and other parameters are adjustable and controllable, and multiple parameter data curves are displayed simultaneously. It is an ideal tool for intermittent hypoxia experiments and one of the most popular intermittent hypoxia modeling devices on the market.

Shanghai Yuyan Scientific Instrument Co., Ltd., as the general agent of Italian company Ugo Basile in China, has long been working closely with Ugo Basile and has jointly explored long-term development plans and strategic cooperation agreements with the two parties, bringing the world's leading pain research equipment and providing comprehensive technical support to the vast number of pain researchers in China.

As we explore the frontiers of life science, we should care more about the welfare of every experimental animal.Shanghai Yuyan Scientific Instrument Co., Ltd.'s integrated euthanasia system provides a painless farewell for experimental animals in a humane, safe and efficient manner.Let us join hands with Yuyan to respect life and promote the harmonious development of science and ethics.

Yuyan Instruments' whole-body exposure and poisoning system is an advanced experimental equipment designed based on the principle of aerosol atomization drug delivery. It adopts the design concept of dynamic cycle exposure and poisoning, and is equipped with an aerosol generation system. It provides a simple, efficient, stable and cost-effective solution for experiments such as toxicology, pharmacodynamics and pharmacokinetic research, and animal modeling.Its experimental results have been widely recognized as important indicators for the toxicity evaluation of various drugs, molecules, particles, etc., providing strong technical support for drug development and optimization.

Yuyan Instruments' Microsprayer Aerosolizer, also known as an intratracheal aerosol drug delivery device, is a device specifically designed for small animals such as mice, rats, and guinea pigs that can accurately deliver intratracheal aerosol drug delivery.The quantitative liquid can be atomized through the aerosol atomization micro nozzle integrated in the stainless steel capillary cannula. The capillary cannula can penetrate deep into the animal to the bronchial bifurcation to achieve quantitative atomization into aerosol drug delivery in the trachea.Compared with traditional oral or injection administration, drugs can act directly on the lungs and are suitable for lung physiology, pathology, and pharmacology research. According to the different states of administration, they can also be divided into liquid administration and dry powder administration.